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Our scientific assessment journey 

The science behind IQOS

Scientific program

We have developed a comprehensive step-by-step scientific assessment program. This program is inspired by the practices of the pharmaceutical industry and is in line with the FDA’s 2012 guidance on the assessment of candidate Modified Risk Tobacco products. Our assessment was also conducted according to international standards.
In laboratory settings, we found that IQOS’ tobacco vapor is less toxic than cigarette smoke.

Our scientists test our products thoroughly before they go into adult smokers’ hands. Using in vitro assays in our labs, we assessed the cytotoxicity and genotoxicity of IQOS tobacco vapor in comparison with the smoke of a reference cigarette designed for research purposes. Taken together, the results of these assays show that IQOS tobacco vapor is significantly less toxic than the smoke from reference cigarette.

Is IQOS less toxic?

In laboratory settings, we found that IQOS’ tobacco vapor is less toxic than cigarette smoke.

Our scientists test our products thoroughly before they go into adult smokers’ hands. Using in vitro assays in our labs, we assessed the cytotoxicity and genotoxicity of IQOS tobacco vapor in comparison with the smoke of a reference cigarette designed for research purposes. Taken together, the results of these assays show that IQOS tobacco vapor is significantly less toxic than the smoke from reference cigarette.
This is just a glimpse of our work. These tests were crucial before we moved on to test IQOS with thousands of adult smokers who voluntarily participated in our clinical study program and ultimately allowed us to commercialize our products.
This is just a glimpse of our work. These tests were crucial before we moved on to test IQOS with thousands of adult smokers who voluntarily participated in our clinical study program and ultimately allowed us to commercialize our products.

Do the significantly lower number and levels of harmful substances in IQOS tobacco vapor also mean lower levels of such substances in the body? If you reduce the level of harmful substances in IQOS tobacco vapor, it would make sense that switching completely to IQOS from cigarettes reduces exposure to these harmful substances. To prove this, we measured biomarkers of exposure for a number of these harmful substances in thousands of smokers who participated in our clinical study program (some switched to IQOS, while others either continued smoking their cigarette brand or quit for the duration of the study).

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Clinical studies

Do the significantly lower number and levels of harmful substances in IQOS tobacco vapor also mean lower levels of such substances in the body? If you reduce the level of harmful substances in IQOS tobacco vapor, it would make sense that switching completely to IQOS from cigarettes reduces exposure to these harmful substances. To prove this, we measured biomarkers of exposure for a number of these harmful substances in thousands of smokers who participated in our clinical study program (some switched to IQOS, while others either continued smoking their cigarette brand or quit for the duration of the study).

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These studies show that when smokers switch to IQOS, their body absorbs significantly lower levels of harmful substances, which in turn results in favorable changes in a number of risk markers selected because of their known association with smoking-related diseases.

But it doesn’t end there.
Our clinical study participants who switched to IQOS also report that IQOS provides comparable levels of satisfaction as cigarettes. This supports our view that IQOS has the potential to be an acceptable alternative for adult smokers who would otherwise continue to smoke. Based on all the scientific evidence, we are confident that switching completely to IQOS is less harmful than continuing to smoke cigarettes.

IQOS satisfaction

Our clinical study participants who switched to IQOS also report that IQOS provides comparable levels of satisfaction as cigarettes. This supports our view that IQOS has the potential to be an acceptable alternative for adult smokers who would otherwise continue to smoke. Based on all the scientific evidence, we are confident that switching completely to IQOS is less harmful than continuing to smoke cigarettes.
However, and this is important: IQOS is not risk-free and the reduction in risk also depends upon each individual’s smoking history. The absolute best choice remains to quit tobacco and nicotine use altogether. IQOS is not an alternative to cessation. It delivers nicotine, which is addictive.
However, and this is important: IQOS is not risk-free and the reduction in risk also depends upon each individual’s smoking history. The absolute best choice remains to quit tobacco and nicotine use altogether. IQOS is not an alternative to cessation. It delivers nicotine, which is addictive.

Once IQOS is available in the market, the research moves from being conducted in a pre-market setting to a real-world post-market setting. There, we look at how the product is being used and by whom in order to complement our pre-market findings and to do our best to identify and prevent use or uptake by unintended audiences. After years of commercialization in many countries, the available data confirms our pre-market observations, in particular in terms of IQOS’ appeal to adult smokers and the relative lack of interest in former and never smokers.

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Long term studies

Once IQOS is available in the market, the research moves from being conducted in a pre-market setting to a real-world post-market setting. There, we look at how the product is being used and by whom in order to complement our pre-market findings and to do our best to identify and prevent use or uptake by unintended audiences. After years of commercialization in many countries, the available data confirms our pre-market observations, in particular in terms of IQOS’ appeal to adult smokers and the relative lack of interest in former and never smokers.

DISCOVER

We also monitor reports of health effects now that the product is used by millions of adult users. Long-term studies will eventually help us to evaluate the potential disease–specific risk reduction of IQOS. Gathering data to answer this question takes time, but it’s the right choice. So far, all the data we’ve seen points in the right direction.

IQOS is a better choice than continued smoking.

The totality of scientific evidence available to-date clearly demonstrates that switching completely to IQOS presents better alternative than continuing to smoke cigarettes.*

Important information: IQOS is not risk free. It delivers nicotine, which is addictive.
IQOS is not risk free and delivers nicotine, which is addictive. The best decision any smoker can make is to quit tobacco and nicotine use altogether.
* Source: Based on the totality of evidence available for IQOS in comparison with continuing to smoke, which includes data on aerosol chemistry from 10 clinical studies conducted with thousands of participants in the US, Japan and Poland, and data from 18 non-clinical studies.

The result:

IQOS is a better choice than continued smoking.

The totality of scientific evidence available to-date clearly demonstrates that switching completely to IQOS presents better alternative than continuing to smoke cigarettes.*

Important information: IQOS is not risk free. It delivers nicotine, which is addictive.
IQOS is not risk free and delivers nicotine, which is addictive. The best decision any smoker can make is to quit tobacco and nicotine use altogether.
* Source: Based on the totality of evidence available for IQOS in comparison with continuing to smoke, which includes data on aerosol chemistry from 10 clinical studies conducted with thousands of participants in the US, Japan and Poland, and data from 18 non-clinical studies.
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