Do the significantly lower number and levels of harmful chemicals in IQOS tobacco vapour also mean lower levels of such chemicals in the body? If you reduce the level of harmful chemicals in IQOS tobacco vapour, it would make sense that switching completely to IQOS from cigarettes reduces exposure to these harmful chemicals. To prove this, we measured biomarkers of exposure for a number of these harmful chemicals in thousands of smokers who participated in our clinical study programme (some switched to IQOS, while others either continued smoking their cigarette brand or quit for the duration of the study). These studies show that when smokers switch to IQOS, their body absorbs significantly lower levels of harmful chemicals, which in turn results in favorable changes in a number of risk markers selected because of their known association with smoking-related diseases. But it doesn’t end.