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Scientific program


This is just a glimpse of our work. These tests were crucial before we moved on to test IQOS with thousands of adult smokers who voluntarily participated in our clinical study program and ultimately allowed us to commercialize our products.
This is just a glimpse of our work. These tests were crucial before we moved on to test IQOS with thousands of adult smokers who voluntarily participated in our clinical study program and ultimately allowed us to commercialize our products.

Do the significantly lower number and levels of harmful substances in IQOS tobacco vapor also mean lower levels of such substances in the body? If you reduce the level of harmful substances in IQOS tobacco vapor, it would make sense that switching completely to IQOS from cigarettes reduces exposure to these harmful substances. To prove this, we measured biomarkers of exposure for a number of these harmful substances in thousands of smokers who participated in our clinical study program (some switched to IQOS, while others either continued smoking their cigarette brand or quit for the duration of the study).

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Clinical studies

Do the significantly lower number and levels of harmful substances in IQOS tobacco vapor also mean lower levels of such substances in the body? If you reduce the level of harmful substances in IQOS tobacco vapor, it would make sense that switching completely to IQOS from cigarettes reduces exposure to these harmful substances. To prove this, we measured biomarkers of exposure for a number of these harmful substances in thousands of smokers who participated in our clinical study program (some switched to IQOS, while others either continued smoking their cigarette brand or quit for the duration of the study).

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However, and this is important: IQOS is not risk-free and the reduction in risk also depends upon each individual’s smoking history. The absolute best choice remains to quit tobacco and nicotine use altogether. IQOS is not an alternative to cessation. It delivers nicotine, which is addictive.
However, and this is important: IQOS is not risk-free and the reduction in risk also depends upon each individual’s smoking history. The absolute best choice remains to quit tobacco and nicotine use altogether. IQOS is not an alternative to cessation. It delivers nicotine, which is addictive.

Once IQOS is available in the market, the research moves from being conducted in a pre-market setting to a real-world post-market setting. There, we look at how the product is being used and by whom in order to complement our pre-market findings and to do our best to identify and prevent use or uptake by unintended audiences. After years of commercialization in many countries, the available data confirms our pre-market observations, in particular in terms of IQOS’ appeal to adult smokers and the relative lack of interest in former and never smokers.

DISCOVER

Long term studies

Once IQOS is available in the market, the research moves from being conducted in a pre-market setting to a real-world post-market setting. There, we look at how the product is being used and by whom in order to complement our pre-market findings and to do our best to identify and prevent use or uptake by unintended audiences. After years of commercialization in many countries, the available data confirms our pre-market observations, in particular in terms of IQOS’ appeal to adult smokers and the relative lack of interest in former and never smokers.

DISCOVER

We also monitor reports of health effects now that the product is used by millions of adult users. Long-term studies will eventually help us to evaluate the potential disease–specific risk reduction of IQOS. Gathering data to answer this question takes time, but it’s the right choice. So far, all the data we’ve seen points in the right direction.